David A. Henderson, M.D., F.A.C.C.
OFFICE LOCATIONCardiology Research Associates (1999-Present)
TELEPHONE:Office: 386-615-1521
Support Staff:Deborah Outler, R.N. |
EDUCATION
1972-1975 |
Marshall University |
1976-1980 |
West Virginia University School of Medicine |
1980-1981 |
Straight Medical Internship |
1981-1983 |
Medical Residency |
1983-1985 |
Fellowship in Cardiology |
MEDICAL LICENSE:
Florida (ME0038731)
CERTIFICATION
1983 |
American Board of Internal Medicine |
1987 |
Subspecialty Board of Cardiovascular Disease |
1999 |
Interventional Cardiology |
2002 |
Nuclear Cardiology |
PROFESSIONAL SOCIETIES
Fellow- American College of Cardiology
American Medical Association
Volusia County Medical Society
Florida Medical Association
Heart Rhythm Society
HOSPITAL AFFILIATIONS
1985-Present |
Florida Hospital Memorial Division |
1985-Present |
Halifax Medical Center |
OFFICES HELD
1993-1995 |
Chief of Medicine, Florida Hospital Memorial Division, |
1999-2001 |
Chief of Staff, Florida Hospital Memorial Division |
2002-Present |
Chairman of Pharmacy and Therapeutics Committee |
2005-Present |
Chairman Facilities and Finance Committee |
ORIGINAL RESEARCH AND PUBLICATIONS
1) Henderson, D.A. and Bowyer, A.F.: Feasibility of Direct Coronary
Blood Flow Measurements in Intact Human
Subjects. West Virginia Medical Journal. September 1978 (abstract).
2) Henderson, D.A. (et.al.): Hospital Cost Containment: A Little Knowledge
Helps. Abstract & Oral Presentation
American Federation for Clinical Research. Spring Meeting April 1987.
Washington.
3) Henderson, D.A. and Morgan, E.M.: Pneumomediastinum As a Complication
of Athletic Competition. Thorax 36 (2): 155. 1981.
RESEARCH ACTIVITY
CONGESTIVE HEART FAILURE
Principal Investigator for Pfizer in trial of Effects of Eplerenone vs
Placebo on CV mortality and HF hospitalization in patients with NYHA Class
II Chronic systolic HF. (EMPHASIS)
Sub-Investigator for Scios in two clinical trials utilizing intravenous
Natrecor in the treatment of decompensated congestive heart failure.
Sub-Investigator for SmithKline Beecham in a clinical trial for the treatment
of stable NYHA Class II-III congestive heart failure. (ENCOR)
Sub-Investigator for Bristol-Myer Squibb in a clinical trial evaluating
patients with chronic heart failure NYHA Class II-IV. (OVERTURE)
Sub-Investigator for Searle Pharmaceutical in a clinical trial for the
treatment of heart failure following an acute myocardial infarction. (EPHESUS)
Principal Investigator for Centocor Phase II clinical trial for the treatment
of heart failure Class III or IV evaluating the effects of Infliximab
(Remicade) – (ATTACH)
Principal Investigator for St. Jude Medical in a heart failure Class III
or IV ventricular resynchronization therapy randomized trial. (VECTOR)
Sub-Investigator for Myogen in an advanced heart failure Class III or IV
placebo-controlled phase III clinical trial. (ESSENTIAL)
Sub-Investigator for Otsuka Maryland Research Institute Incorporated,
Multi-center, Randomized, Double-Blind, Placebo Controlled Study to
Evaluate the Long Term Efficacy and Safety of Oral Tolvaptan Tablets in
Subjects Hospitalized with Worsening Congestive Heart Failure. (EVEREST)
LEFT VENTRICULAR DYSFUNCTION
Sub-Investigator for Norvartis in a clinical trial for treatment of high-risk patients after myocardial infarction. (VALIANT)
ACUTE MYOCARDIAL INFARCTION
Principal Investigator for Astra Zeneca in a randomized clinical trial
(PLATO)A Study of PLATelet inhibition and Patient Outcomes.
Sub-Investigator for Centocor in a clinical trial for the treatment of
acute myocardial infarction. (GUSTO V).
ACUTE CORONARY SYNDROME
Principal Investigator for Schering Plough in tiral to evaluate safety
and efficacy of SCH530348 in addition to standard care in patients with ACS. (TRACER)
Principal Investigator for Schering Plough in trial of Benefit and Safety
of Vytorin vs Simvastatin monotherapy in high risk subjects presenting with
ACS. (IMPROVE-IT)
Principal Investigator for Roche Pharmaceuticals in a clinical trial for
treatment of patients post acute coronary syndrome. (2nd SYMPHONY)
Sub-Investigator for Bristol Myers Squibb in a clinical trial for treatment
of patients post acute coronary syndrome. (PROVE IT)
Sub-Investigator for Aventis open-label enoxaparin versus UFH in subjects
who present to the emergency room with ACS. (RESCUE)
Sub-Investigator for AstraZeneca in a 12-Week, Randomized, Open-Label,
3-Arm, Parallel Group, Multicenter, Phase IIIb Study Comparing the
Efficacy and Safety of Rosuvastatin 20 mg and 40 mg with that of
Atorvastatin 80 mg in Subjects with Acute Coronary Syndromes. (LUNAR)
Principal Investigator for Eli Lilly in a Comparison of CS-747(Prasugrel)
and Clopidogrel in Acute Coronary Syndrome Subjects who are to Undergo
Percutaneous Coronary Intervention/TIMI-38 (TRITON)
ISCHEMIC/STABLE ANGINA
Principal Investigator for Momenta in trial to evaluate safety and
efficacy of M118 in PCI in patients with stable CAD (EMMINENCE)
Principal Investigator for Schering Plough in trial to evaluate safety
and efficacy of SCH530348 in addition to standard care in patients with
atherosclerotic disease. (TIMI 50)
Sub-Investigator for Parke Davis in the treatment of patients with
coronary artery disease, silent ischemia, and effort –induced angina. (QUASAR)
ARRHYTHMIAS
Principal investigator for Sanofi Aventis study to Assess Efficacy
of Dronedarone for prevention of CV hospital izations or death from
any cause in patients with AF /AFL. (ATHENA)
Principal Investigator for Sanofi Aventis toevaluate dronedarone vs amiodarone
for maintenance of sinus rhythm in patients with AF (DIONYSOS)
Sub-Investigator for Knoll Pharmaceutical Company in the prevention of
symptomatic recurrences of atrial fibrillation. (RAFT)
Principal Investigator for Proctor and Gamble, A Multi-Center, 12-Month
Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the
Efficacy and Safety of 75 and 125 mg Doses of Oral Azimilide Dihydrochloride
in Patients with an Implantable Cardioverter Defibrillator for the
Treatment of Ventricular Arrhythmia. (SHIELD)
Principal Investigator for Proctor and Gamble, A Multi-Center, Open Label,
Follow-Up Study to Assess the Long-Term Safety of 125 mg per day of Oral
Azimilide Dihydrochloride in Patients with an Implantable Cardioverter
Defibrillator. (SHIELD OPEN LABEL)
Principal Investigator for Proctor and Gamble to assess Azimilide
Dihydrochloride for the treatment of atrial fibrillation in patients
who require electrical cardioversion, with an open-label follow-up
phase to assess the long-term efficacy and safety. (A-COMET I)
Principal Investigator for Proctor and Gamble to assess Azimilide
Dihydrochloride for prophylactic treatment of atrial fibrillation
and an open-label follow-up to assess the long-term efficacy and
safety. (A-STAR)
Principal Investigator for Sanofi-Aventis in a Placebo-Controlled,
Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone
400mg bid for the Prevention of Cardiovascular Hospitalization or Death
From Any Cause in Patients with Atrial Fibrillation/Atrial Flutter (ATHENA)
ANTI-COAGULANT
Principal Investigator for Sanofi Aventis in a study of safety and
efficacy of idraparinux in prevention of stroke and thrombotic events
in patients with AF. (BOREALIS)
Principal Investigator for Aryx in a trial of ATI 5923 in comparison
with warfarin (EMBRACE AC)
Sub investigator for Boehiner Ingleheim In a trial of dabigatran for
prevention of stroke and septic embolism in patients with nonvalvular AF (RELY)
Sub-investigator for Astra Zeneca in a clinical trial to compare an oral
direct thrombin inhibitor to dose-adjusted Coumadin in patients with
atrial fibrillation. (SPORTIF V)
Sub-Investigator for Boehringer Ingelheim in a Randomized Evaluation of
Long Term Anticoagulant Therapy Comparing the Efficacy and Safety of
Two Blinded Doses of Dabigatran Etxilate with Open Label Warfarin for
the Prevention of Stroke and Systemic Embolism in Patients with
Non-Valvular Atrial Fibrillation: Prospective, Multi-Centre,
Parallel-Group, Non-Inferiority Trial (RELY)
ANTI-PLATELET AGGREGATION
Principal Investigator for Astra Zeneca in a randomized clinical
trial (PLATO)A Study of PLATelet inhibition and Patient Outcomes.
Sub-Investigator for Bristol-Myers Squibb and Sanofi-Snythelabo, Atrial
Fibrillation Clopidogrel Trial with Irbesartan for Prevention of
Vascular Events. (ACTIVE)
HYPERLIPIDEMIA
Principal Investigator for Schering Plough in trial of Benefit and
Safety of Vytorin vs Simvastatin monotherapy in high risk subjects
presenting with ACS. (IMPROVE-IT)
Sub-Investigator for Pfizer in an open-label 8-week treatment clinical
trial evaluating Atorvastatin doses in dyslipidemic patients. (AT GOAL)
Sub-Investigator for AstraZeneca in a placebo-controlled, phase III,
clinical trial in the prevention of cardiovascular events among
subjects with low levels of LDL-C and elevated levels of C-Reactive
Protein (JUPITER)
CLAUDICATION
Sub-Investigator for Otsuka Pharmaceuticals in a clinical trial to assess the long-term effects of Pletal versus placebo for patients with intermittent claudication secondary to peripheral arterial disease. (CASTLE)
HYPERTENSION
Sub-investigator for Bristol Myers Squibb in a clinical trial of Omapatrilat versus Enalapril in mild-moderate/severe hypertension. (OCTAVE)
LEFT VENTRICULAR HYPERTROPHY
Principal Investigator for Norvartis in a multi-center, randomized,
Double-Blind parallel group study to evaluate the efficacy of Lotrel and
benazepril/hydrochlorothiazide in the regression of left ventricular
hypertrophy by magnetic resonance imaging in patients with high risk
hypertension. (ALIVE)
Sub-Investigator for GlaxoSmithKline in a randomized, double-blind,
multi-center study comparing the effects of Carvedilol modified
release formulation (COREG) and Atenolol in combination with and
compared to an Angiotensin converting enzyme inhibitor (LISINOPRIL)
on left ventricular hypertrophy. (CLEVER)
PCI STUDIES
Principal Investigator for Schering-Plough in a Multi-Center, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety of SCH 530348 in Subjects Undergoing Non-Urgent Percutaneous Coronary Intervention (TRA)
METABOLIC SYNDROME STUDIES
Principal Investigator for Sanofi Aventis in a study of Rimonabant for reducing the risk of major CV events in abdominally obese patients with clustering of risk factors. (CRESCENDO)
PACEMAKER DEVICE TRIALS
Investigator for evaluation of St. Jude steroid active fixaton lead.
Investigator for St. Jude VDD pacing system.
Investigator for St. Jude AMPS trial: Atrial fibrillation and mode
switching pacemaker study.
Principal Investigator for St. Jude in the TENDRIL FSR 1699T Lead
Clinical Study 07/30/08
PUBLISHED ARTICLES
A Novel Lead Design Reduces Far Field R-Waves (FFRWs) and Decreases the Incidence of Inappropriate Automatic Mode Switch Episodes
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